Effects of Boswellia species on viral infections with particular attention to SARS-CoV-2Article Published on 2022-10-012022-11-15 Journal: Inflammopharmacology [Category] COVID19(2023년), SARS, 치료제, [키워드] activity antiviral activity antiviral drugs Antiviral effect antiviral property Boswellia Boswellia species bronchial asthma caused condition COVID-19 pandemic disease drugs Effect Efficacy exhibited Herbal herbal medicine natural Natural therapies pathogenic virus pharmacological plants provided reduction in reported Research SARS-CoV-2 SARS-CoV-2. therapeutic effect Topic Treatment Vaccine Viral diseases viral infection Viral resistance [DOI] 10.1007/s10787-022-01037-4 PMC 바로가기
Understanding the genetics of viral drug resistance by integrating clinical data and mining of the scientific literature임상 데이터 통합 및 과학 문헌 마이닝을 통한 바이러스성 약물 내성 유전학 이해Article Published on 2022-08-252022-09-11 Journal: Scientific Reports [Category] B형 간염, SARS, 변종, 치료제, [키워드] Analysis analysis approach article assist binding pocket caused Clinical data clinical study clinically compendium Disulfide disulfide bond drug drug resistance entecavir Evidence genetic mutation genetic mutations genetics Genotype HBV hepatitis B Hepatitis B virus identify information location Mutation mutational hotspot Mutational hotspots mutations Perspective phenotype public health threat PubMed Central robust SARS-CoV-2 understanding viral disease Viral diseases Viral resistance virus viruses [DOI] 10.1038/s41598-022-17746-3 PMC 바로가기 [Article Type] Article
Evolutionary and Structural Insights about Potential SARS-CoV-2 Evasion of NirmatrelvirNirmatrelvir의 잠재적인 SARS-CoV-2 회피에 대한 진화적 및 구조적 통찰력Review Published on 2022-07-142022-09-11 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis analyzed antibody approval arises broad-spectrum antiviral broad-spectrum antivirals combination therapy COVID-19 pandemic drug-resistant indicate inhibitor insight M pro Mutation Nirmatrelvir Paxlovid Potential Pro protease residue residues Ritonavir SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants significantly U.S. FDA Vaccine Viral resistance viral variant [DOI] 10.1021/acs.jmedchem.2c00404 PMC 바로가기 [Article Type] Review
Comprehensive fitness landscape of SARS-CoV-2 M pro reveals insights into viral resistance mechanismsSARS-CoV-2 M pro의 종합적인 피트니스 환경은 바이러스 저항 메커니즘에 대한 통찰력을 보여줍니다Article Published on 2022-06-202022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition Amino acid amino acid changes amino acids analyzed Anti-viral drugs can be used cleave Complete Comprehensive conserved contribute Coronavirus-2 correlated Critical deep mutational scanning deep sequencing defined drug drug design drug resistance Effect effective elicit evade Evolution Evolutionary biology expression functional human population Infectious disease inhibitor inhibitors life cycle M pro main protease mechanism Microbiology Microbiology. MPro Mutation network new strain performed physically protease Protein reduced reveal S. cerevisiae SARS-CoV-2 SARS-CoV-2 main protease selection pressure Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Toxicity Vaccines variant viral life cycle Viral resistance virulent yeast [DOI] 10.7554/eLife.77433 PMC 바로가기 [Article Type] Article
Suspect screening of wastewaters to trace anti-COVID-19 drugs: Potential adverse effects on aquatic environment항-COVID-19 약물 추적을 위한 폐수 의심 스크리닝: 수생 환경에 대한 잠재적인 역효과Article Published on 2022-06-102022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] adverse effect antibiotic Antibiotic resistance Antibiotics antiviral drugs approach Aquatic ecosystems aquatic environment average Azithromycin Care ciprofloxacin Cluster Compound conducted COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic COVID-19 patients COVID-19 treatment deaths drug drugs Drugs consumption ecological eight Epidemiology European Evidence evidenced Health highest hospital Hydroxychloroquine lack liquid Liquid chromatography list lombardy management mass mass spectrometry metabolite pandemic plants positively correlated Potential protocol receiving Resolution risk SARS-CoV-2 SARS-CoV-2 pandemic Spectrometry starting Suspect screening the SARS-CoV-2 Therapeutic treatment Toxicity Treatment treatment of COVID-19 patients Viral resistance Wastewater-based epidemiology. water water bodies water body were measured [DOI] 10.1016/j.scitotenv.2022.153756 PMC 바로가기 [Article Type] Article
Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus Research Published on 2022-04-152022-10-05 Journal: Genes and Immunity [Category] 바이오마커, [키워드] amplified Analysis Antigen association Blood Cohort contributing to defined DEGs described differentially expressed gene Donor Effects enrichment analysis explain females genomic data Health healthy individual IFNγ immune response immunology individual individuals Infectious disease influenza A virus Influenza virus LPS male males milieu no significant difference potential mechanism regression analysis report response RHD SNP stimulated susceptibility transcriptomic viral infections Viral resistance [DOI] 10.1038/s41435-022-00169-5 [Article Type] Research
mTOR kinase is a therapeutic target for respiratory syncytial virus and coronavirusesArticle Published on 2021-12-242022-10-04 Journal: Scientific Reports [Category] 치료제, [키워드] absence antiviral agent antiviral drugs approach approach approaches cause cellular children coronavirus coronavirus described disease effective effective antiviral treatment Factors function Gene Expression Host Infant Infection Intervention kinase life-threatening Lower respiratory tract Mild Molecular biology mRNA mTOR signaling progeny Protein reduce respiratory respiratory pathogen respiratory syncytial virus respiratory tract infection RSV shown Symptom therapeutic target Transcription upper respiratory tract Vaccine Viral host response viral infection viral infections viral pathogenesis Viral resistance virus while [DOI] 10.1038/s41598-021-03814-7 PMC 바로가기 [Article Type] Article
Imiquimod Boosts Interferon Response, and Decreases ACE2 and Pro-Inflammatory Response of Human Bronchial Epithelium in AsthmaImiquimod는 인터페론 반응을 높이고 ACE2 및 천식에서 인간 기관지 상피의 염증 반응을 감소시킵니다Immunology Published on 2021-12-072022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료법, [키워드] ACE2 ACE2 expression analyses Analysis analysis analyzed Anti-inflammatory Anti-viral anti-viral cytokine anti-viral cytokines anti-viral drug Anti-viral treatment Asthma asthmatic Asthmatic patients baseline bronchial bronchial epithelial cell COVID-19 COVID-19 infection cytokine cytokine signaling Cytokines decrease donors drug dsRNA dual Effect ELISA epithelial epithelial cells epithelium Ex vivo examined exhibit expression feasibility HBEC HBECs healthy highlight Human IFN signaling IFN-β IL-1β IL-33 IL-6 IL-8 imiquimod IMPROVE infections involved mechanism mRNA multiplex objective pathway poly(I:C poly(I:C) pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines producing protective effect proteomic qPCR Receptor binding reduced reducing resistance mechanisms response Result RT-qPCR SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Severe COVID-19 Infection SP1 spike-protein stimulated subjects suppression target TLR7 TLR7 agonist Tolerance treat Treatment Trigger triggers Viral viral infection viral infections Viral resistance western blot [DOI] 10.3389/fimmu.2021.743890 PMC 바로가기 [Article Type] Immunology
Nanovesicles derived from bispecific CAR-T cells targeting the spike protein of SARS-CoV-2 for treating COVID-19COVID-19 치료를 위한 SARS-CoV-2의 스파이크 단백질을 표적으로 하는 이중특이성 CAR-T 세포에서 유래한 나노소포Research Published on 2021-11-252022-09-10 Journal: Journal of Nanobiotechnology [Category] MERS, 진단, 치료제, [키워드] ADE Adverse drug reactions Antibody-dependent enhancement Antibody-mediated neutralization Antiviral antiviral drug antiviral drugs binding ability CAR-T CAR-T cell caused Cell co-expression COVID-19 COVID-19 pandemic CR3022 develop dilemma drug drugs effective Effects epitope Epitopes Express facilitate Fc fragment help incidence Infection inhibiting lack nanovesicles neutralization neutralize Neutralizing antibodies neutralizing antibody overexpressing present Prevent problem Pseudotyped virus reduce reducing Remdesivir Result SARS-CoV-2 SARS-CoV-2 spike protein scFv selective single antibody Spike protein spike protein of SARS-CoV-2 supplementary material T cells Targeted delivery the spike protein Therapeutic approach toxic effect treat treating COVID-19 Treatment treatment of COVID-19 variable Viral viral infection viral replication Viral resistance virus [DOI] 10.1186/s12951-021-01148-0 PMC 바로가기 [Article Type] Research
Clinically Relevant Influenza Virus Evolution Reconstituted in a Human Lung Airway-on-a-ChipResearch Article Published on 2021-09-152022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Administered airway Antiviral antiviral drug antiviral therapies approach clinical clinically Combination contribute coronavirus Coronaviruses creating Culture droplet drug drug resistance effective vaccine epidemiological Evolution Factor gene reassortment Host Human human host human lung human populations human-to-human transmission humans in vitro induce Infection influenza A virus influenza infection influenza viral Influenza virus influenza virus inhibitor lack lung airway-on-a-chip modeling Mutation mutations new strain occur oseltamivir Pandemics preclinical model prevalent promote SARS-CoV-2 serine proteases strain traits Transmission Vaccines variant viral evolution Viral resistance virus viruses [DOI] 10.1128/Spectrum.00257-21 PMC 바로가기 [Article Type] Research Article